Investigation concerning the pathogenesis of septic condition, and development of new therapy by PPARγ activation in monocytic cells.

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We obtained macrophage from healthy volunteers. After the differentiation into macrophage, they were cultured in different glucose concentrations of cell culture liquid for 72 hours after lipopolysaccharide administration. High glucose conditions reduced phagocytic ability and exaggerated cell death in macrophage by the activation of endoplasmic reticulum stress. Ghrelin administration reversed these effects through peroxisome proliferator-activated receptor (PPARγ) activation.