The combined effect of emdogainRgel and bioactive glass in the healing of cranial bone defect in rats.

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The purpose of this study was to investigate the effects of EmdogainRgel (EMD) on the injured open-apex within the periapical lesions. The rats were sacrificed 28 days after treatment and prepared for immunohistochemical examination. At 28days after the treatment, the mean area of newly formed cementum in the EMD group was significantly larger than in the control group. These results suggest that, EMD may have the benefit efficacy to create a favorable environment promoting wound healing of destroyed periapical tissues.In addition, the purpose of this study was to investigate the combination effects of EMD and bioactive glass(BAG) in the healing of cranial bone defect in rats. At 28 days after the treatment, the mean area of newly formed bone in the EMD+BAG group was significantly larger than that in the control group. These results suggest that a combination of EMD and BAG enhances the cranial bone healing process in rats, suggesting it could be useful for bone regeneration.