Evaluation of bone regeneration using the hybrid materials of autogenous plasma and bone marrow mesenchimal stem cells

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This study evaluated the effect of autogenous plasma and platelet-released growth factors to bone formation. PPP, PRP and PRF were implanted to each extraction socket in canine mandible. The amount of new bone formation was the highest in the PPP group, PPP and PRF could sufficiently maintain the bone width and height of the socket. β-TCP with bone marrow aspirate concentrate was implanted into the back muscle of dogs. This study indicated that BMAC comprises concentrated bone marrow stem cells and a fibrin scaffold that has the ability to induce ectopic bone formation