The effect of glycosyltransferase GnT-V in the development and progression of oral cancer and evaluation by PET.

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The pattern and expression of cell surface sugar chains greatly alter during the carcinogenesis and play important role in tumor progression. To clarify the role of glycosyltrasferase GnT-V in cancer development we examined the expression of GnT-V in the oral cancer association with the PET scan. Both GnT-V mRNA and protein are strongly enhanced in oral cancer compared with normal oral mucosa tissue. In the group with high SUV on FDG-PET and FMISO-PET hypoxia imaging, GnT-V and HIF-1α had tendency to express higher. The expression and function of GnT-V may increase in hypoxia condition. By treatment the human oral squamous cell carcinoma cell line SAS with swainsonine, an inhibitor of N-glycan processing, cell motility was reduced significantly. These results showed that the glycosylation by GnT-V is associate with cell motility and invasion enhancement in oral cancer and related in oral cancer progression.