Development of therapeutic drug for osteoporosis using DHNA

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This application study was that relevant, to verify the effects of as therapeutic agents for osteoporosis, especially to bone metabolism as a new possibility of 1,4-dihydroxy-2-naphthoic acid of (DHNA). Showed an improvement of bone density of osteoporosis results DHNA administration and verified by three-dimensional bone analysis using micro-CT to the effects of osteoporosis DHNA of osteoporosis in animal models at the beginning. A result of the analysis of mechanisms to improve bone density of osteoporosis of DHNA, increase of calcification degree of osteoblast induction experiments, alkaline phosphatase activation rise was confirmed. Was suggested that there is a differentiation inhibitory effect against osteoclasts involved in bone formation in the promotion of bone matrix mainly DHNA than or more.