Establishment of peptide vaccine therapy using novel tumor refusal antigens for oral cancer

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In our department, there are new patients of oral cancer withmore than 80 people a year. No treatment against sever advanced or recurrent cases, sodevelopment of a new treatment is desired. We therefore prepared three of HLA-restrictedpeptides in the target molecule which are expressed specifically in oral cancer tissue,we have administered peptides vaccine to 43 patients in the past. As a result, it waspossible to reject her tumor completely, and to obtain CR in one case. In most cases,the induction of killer T cells recognizing the peptide was confirmed.In addition, wecan also confirm of their extended both OS and PFS.