Investigation of the mechanism of cartilage destruction induced by COX-2 in temporomandibular joint osteoarthrosis and establishment of anti-inflammatory drug treatment

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The excessive mechanical stress up-regulated COX-2 and MMP-1, 3, 9 in cultured chondrocyte derived from porcine condylar cartilage. Furthermore, the presence of Celecoxib decreased the gene expressions induced by mechanical stress. The presence of Celecoxib counteracted expressions of typeIIcollagen, aggrecan mRNA, however, the treatment of Indomethacin and Andamfenac sodium had no effect on these gene expression. Celecoxib showed a protective effect on extracellular matrix turnover by attenuating the influence of excessive mechanical stress on chondrocytes.