Investigation of the mechanism of cartilage destruction induced by COX-2 in temporomandibular joint osteoarthrosis and establishment of anti-inflammatory drug treatment

COX-2致颞下颌关节骨关节炎软骨破坏的机制探讨及抗炎药物治疗的建立

• 批准号: 23792429
• 负责人: TANNE Yuki
• 金额: $ 2.58万
• 依托单位: Hiroshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23792429/
• 关键词: 変形性顎関節症; NSAID; 薬学

The excessive mechanical stress up-regulated COX-2 and MMP-1, 3, 9 in cultured chondrocyte derived from porcine condylar cartilage. Furthermore, the presence of Celecoxib decreased the gene expressions induced by mechanical stress. The presence of Celecoxib counteracted expressions of typeIIcollagen, aggrecan mRNA, however, the treatment of Indomethacin and Andamfenac sodium had no effect on these gene expression. Celecoxib showed a protective effect on extracellular matrix turnover by attenuating the influence of excessive mechanical stress on chondrocytes.

过度机械应力上调猪髁突软骨细胞中COX-2和mmp - 1,3,9的表达。此外，塞来昔布的存在降低了机械应力诱导的基因表达。塞来昔布的存在抵消了ii型胶原蛋白、聚集蛋白mRNA的表达，而吲哚美辛和安达芬酸钠对这些基因的表达没有影响。塞来昔布通过减弱过度机械应力对软骨细胞的影响，显示出对细胞外基质周转的保护作用。

项目成果

Effect of Celecoxib on extracellular matrix metabolism in mandibular condyle chondrocytes underexcessive mechanical stress

塞来昔布对过度机械应力下下颌髁突软骨细胞细胞外基质代谢的影响

• 发表时间: 2012
• 作者: Shimizu Y;Hosomichi J;Kaneko S;Shibutani N;Ono T.;臼見莉沙，小野法明，細道純，渋谷直樹，金香佐和，小野卓史;Tanne Yuki
• 通讯作者: Tanne Yuki

Effects of COX-2 inhibitor on the metabolism of extracellular matrix in stressed TMJ chondrocyte

COX-2抑制剂对应激TMJ软骨细胞细胞外基质代谢的影响

• 发表时间: 2012
• 作者: Shimizu Y;Hosomichi J;Kaneko S;Shibutani N;Ono T.;臼見莉沙，小野法明，細道純，渋谷直樹，金香佐和，小野卓史;Tanne Yuki;Su Shaoching
• 通讯作者: Su Shaoching

Effect of Celecoxib on extracellular matrix metabolism in mandibular condyle chondrocytes under excessive mechanical stress

塞来昔布对过度机械应力下下颌髁突软骨细胞细胞外基质代谢的影响

• 发表时间: 2012
• 作者: Shimizu Y;Hosomichi J;Kaneko S;Shibutani N;Ono T.;臼見莉沙，小野法明，細道純，渋谷直樹，金香佐和，小野卓史;Tanne Yuki;Su Shaoching;Su S.C.;Tanne Y.
• 通讯作者: Tanne Y.

The direct effect of high magnitude cyclic tensile stress on COX-2 and MMPs expressions in chondrocytes derived from mandibular condyle

高强度循环拉伸应力对下颌骨髁突软骨细胞 COX-2 和 MMPs 表达的直接影响

• 发表时间: 2011
• 作者: Shimizu Y;Hosomichi J;Kaneko S;Shibutani N;Ono T.;臼見莉沙，小野法明，細道純，渋谷直樹，金香佐和，小野卓史;Tanne Yuki;Su Shaoching;Su S.C.;Tanne Y.;Su Shaoching
• 通讯作者: Su Shaoching