Effects of enamel matrix protein on the metabolism of periodontal tissue and application of enamel matrix protein for orthodontic treatment.

研究表明，人全长釉原蛋白通过MAPK-ERK信号通路与CD 63相互作用，促进人成牙骨质细胞系细胞的增殖。此外，釉原蛋白上调人成牙骨质细胞成骨分化过程中骨特异性标志物的表达和矿化活性。在体内研究中，它表明，釉原蛋白的应用肯定抑制根吸收。因此，证实釉原蛋白可能通过促进人成牙骨质细胞系细胞的增殖和分化而促进牙骨质的再生，表明釉原蛋白在牙周组织再生中的应用。

It is demonstrated that human full-length amelogenin enhances the proliferation of human cementoblasts lineage cells by an interaction with CD63 through MAPK-ERK signaling pathway. In addition, amelogenin up-regulated the expressions of bone specific marker and mineralization activity in the osteogenic differentiation of human cementoblasts. In vivo studies,it is demonstrated that application of amelogenin surely suppresses root resorption. It is thus confirmed that amelogenin may contributeto the regeneration of cementum in terms of the enhancement of human cementoblast lineage cells proliferation and differentiation, indicating an application of amelogenin to regeneration of periodontal tissue.