The development of a new route of administration to relieve the side effects of Bisphosphonates.

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Bisphosphonates (BPs) have powerful anti- bone-resorptive effects. However, BPs are known to have several undesirable side effects (such as influenzalike fever, gastrointestinal disturbance). Iontophoresis is the one of the electrical methods that have been employed to enhance drug transportation across the skin. Transdermal drug delivery has a number of potential advantages compared with conventional methods: painless, no degradation from passage through the gastrointestinal tract or the liver. BPs were successfully transportedthrough living mouse skin in a dose-, voltage-, and time-dependent manner.