Establishment of the remineralization-promoting treatment and the caries-preventive protocol by novel fissure sealant

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We aimed to evaluate the caries-preventive effect of a fissure sealant containing surface reaction-type pre-reacted glass ionomer (S-PRG) filler. For the sealant containing S-PRG filler, high amount of Sr and B ions was detected, and a considerable amount of fluoride was released after a recharge with a high concentration of fluoride. Moreover, the S-PRG filler-containing sealant bonded by self-etching primer maintained the enamel surface integrity and inhibited enamel demineralization. In addition, the sealant had a higher bond strength on both untreated enamel and enamel subsurface lesions than the conventional resin-based sealants bonded by acid etching. These findings suggest that sealants containing S-PRG filler enhance the enamel demineralization-inhibiting effect and the remineralization-promoting effect for long-term dental care.