Investigation on neural mechanisms of the effect of touch using an indicator of cardiovascular responses to painful stimuli

使用心血管对疼痛刺激反应的指标研究触摸影响的神经机制

• 批准号: 23792575
• 负责人: WATANABE Nobuhiro
• 金额: $ 2万
• 依托单位: Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23792575/
• 关键词: タッチ; 痛み; 循環; 脊髄; μ-オピオイド受容体; オピオイド

The present study examined the effect of gentle cutaneous stimulation (touch) and its mechanism using heart rate responses to noxious heat stimulation as an indicator in anesthetized rats. We found that touch using a soft elastomer brush inhibited heat-induced heart rate responses. Additionally, the inhibitory effect of touch on heart rate responses was abolished by blocking spinal μ-opioid receptors.

本研究以心率对伤害性热刺激的反应为指标，研究了温和皮肤刺激(触摸)对麻醉大鼠的影响及其机制。我们发现，使用软弹性刷子的触摸抑制了热诱导的心率反应。此外，通过阻断脊髓μ-阿片受体，触摸对心率反应的抑制作用被取消。