Elucidation of MMPs in wound healing in a hairless rat model with decubitus ulcer

本研究通过建立无毛大鼠褥疮模型，探讨基质金属蛋白酶对褥疮发生和温泉浴治疗创面愈合的影响。我们的研究结果表明，MMPs在难治性皮肤创伤中的异常表达模式，特别是在创伤愈合过程中细胞生长过程和细胞外基质重塑的调节中。此外，温泉浴对顽固性皮肤创伤的愈合也有促进作用。提示温泉治疗对MMPs表达的影响可能成为促进创面愈合的新手段。

In this study, we developed hairless rat model with decubitus ulcer and investigated the effect of MMPs on the development of decubitus ulcer and wound healing with treatment of hot spring bathing. Our results showed the abnormal expression pattern of the MMPs of intractable skin wound, specifically in regulation of cell growth process and remodeling of extracellular matrix in a wound healing process. Furthermore, the wound healing effect of intractable skin wound appeared by hot spring bathing. These results indicate the changes of MMPs expression by treatment of hot spring may become a new mean to promote wound healing.