Strained alkenes as chemical probes for cysteine sulfenic acid

应变烯烃作为半胱氨酸磺酸的化学探针

• 批准号: DE150101863
• 负责人: Prof Justin Chalker
• 金额: $ 25.66万
• 依托单位: Flinders University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-19 至 2017-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE150101863
• 关键词: Strained; alkenes; chemical; probes; cysteine

This project aims to introduce strained alkenes as probes for cysteine sulfenic acid, a poorly understood biomarker for oxidative stress. This probe will enable rapid detection of cysteine sulfenic acid and meet an urgent need for tools to map cysteine redox signalling. Moreover, since many enzymes feature a cysteine sulfenic acid at their active site, the strained alkene probes will also serve as useful inhibitor probes of these enzymes. Such inhibitor probes will provide critical information for potential therapeutic applications in human conditions associated with oxidative stress such as ageing, cancer, and heart disease.

该项目旨在引入张力烯烃作为半胱氨酸亚磺酸的探针，半胱氨酸亚磺酸是一种鲜为人知的氧化应激生物标志物。这种探针将能够快速检测半胱氨酸磺酸，并满足对绘制半胱氨酸氧化还原信号的工具的迫切需求。此外，由于许多酶的活性部位都有半胱氨酸亚磺酸，因此应变的烯烃探针也将作为这些酶的有用的抑制剂探针。这些抑制物探针将为与衰老、癌症和心脏病等与氧化应激相关的人类疾病的潜在治疗应用提供关键信息。