Development of slab optical waveguide fluorescent microscopy system for the study of heterogeneous chemical reactions of biochemical agents at lipid membrane

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Slab optical waveguide fluorescent microscopy (SOWG-FM) system,which was developed by research representatives was applied to the observation of lipid membrane disruption by antibacterial agent, Gramicidin S (GS). The measurement system has an important advantage in the observation of planar lipid membrane stabilized on a glass surface because its high interfacial selectivity using an evanescent wave illumination.The research representative was developed a visualization method of the planar lipid membrane by an environmentally-responsive fluorescent dye. Lipid membrane disruption by GS and its analog were observed. The results showed good correlation with those antibacterial activities.