Intracellular dynamics of traction forces under physiological mechanical stimulations

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Mechanical stresses induced on our body involve in multiple disorders. In this study, in order to understand how the mechanical stresses involve in those disorders, intracellular alterations of traction force were tried to be measured. For the measurement, measuring system was developed. Moreover, as a mechanism of the alterations, cytoskeletons were considered as a mechanical model. As a result, although alterations of intracellular traction forces remain indispensable noises for valid analysis, those of cellular traction forces were valid. In addition with alterations of cytoskeletons, it was indicated that ablation of cytoskeletons induced several types of alterations in cellular traction forces.