Fabrication of a real-time mechanical stimulus response evaluation microdevice for stem cell differentiation induction

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A real-time mechanical stimulus response evaluation microdevice for differentiation induction of stem cells was fabricated using MEMS technology. The device design, fabrication conditions, and process conditions were determined, and the validity of proposed design and fabrication process of the microdevice was proved. Also, the drive performance of the fabricated microdevice was evaluated. Moreover, deformation behavior and intracellular calcium concentration change of cells to receive the mechanical stimuli on the fabricated microdevice were observed in real time.