The role of mitochondrial dynamics in the interactions between organelles in plants

线粒体与其他细胞器的相互作用在植物的发育和生理功能中起着至关重要的作用。生物素是植物胚胎发生等多种发育过程所必需的辅助因子，是羧化和脱羧反应的重要辅助因子。在这项研究中，我们揭示了生物素的生物合成需要线粒体和过氧化物酶体之间的代谢相互作用，这在植物和真菌中是进化保守的。我们还研究了植物中线粒体和其他细胞器之间的物理接触的作用。MIRO1是一种线粒体GTPase，参与线粒体形态和分布的调节。我们通过表达靶向MIRO1序列的人工微RNA，获得了线粒体细胞内分布异常的转基因细胞系。

Interactions between mitochondria and the other organelles play vital roles in developmental and physiological functions in plants. Biotin, an essential cofactor for carboxylation and decarboxylation reactions, is required for various developmental processes including embryogenesis in plants. In this study, we revealed that biosynthesis of biotin requires the metabolic interaction between mitochondria and peroxisomes, which is evolutionarily conserved in plants and fungi. We have also investigated the role of physical contact between mitochondria and the other organelles in plants. MIRO1 is a mitochondrial GTPase involved in the regulation of mitochondrial morphology and distribution. We generated transgenic lines exhibiting abnormal intracellular distribution of mitochondria by expressing the artificial micro RNA targeting the MIRO1 sequence.