Development of accurate electrostatic potential imaging for visualization of protein function

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In this research, in order to calculate precise electron density, I tried to develop accurate measurement methods of low resolution diffraction data and visualization methods of solvent area structure without error. I constructed a measurement system of precise low resolution data at SPring-8 with high flux X-ray. Los-free diffraction data in low resolution area could be obtained in this system. Heavy atoms, PbEDTA or Xe, for visualization of solvent area could successfully soaked in protein crystal.