Molecular mechanism of the signaling involved in nutrient sensing and cell regulation that mediated by TORC1 in fission yeast

点击翻译按钮获取中文摘要

The TORC1 signaling plays a crucial role in a large number of cellular processes in response to nutrient signals. In this study, we investigated molecular mechanism of the nutrient-dependent TORC1 signaling in the fission yeast Schizosaccharomyces pombeand demonstrated three protein kinases as its substrates. Of these, it was especially revealed how Psk1 is regulated by TORC1 responding to nutrient availability. The findings obtained from this study indicate a milestone to elucidate the universal mechanism of cellular regulation by TORC1 signaling among eukaryotes.