A novel oxidative stressdefense mechanism of Escherichia coliby cysteine/cystine shuttle system play a important role in quality control of membrane phospholipids

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The inducible L-cysteine/L-cystine shuttle system plays an important role on quality control of lipids under oxidative stress. Thiobarbituric acid responsive substances (TBARS) are routinely used to assess oxidative stress damage to membrane lipids in diverse organisms.TBAR content increased ~2-fold when E. coliwas exposed to H2O2, respectively. Even in the absence of toxicant, E. coli ΔydeD/fliYshowed increased (~2-fold) levels of these substances relative to wild-type controls, suggesting that L-cysteine/L-cystine shuttle systemmay function in controlling the level of membrane peroxidation products thatare generated during the normal, basal metabolism.