Search for compounds enhancing cell growth of symbiotic bacteria derived from marine invertebrates

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Sponges are one of the most important marine sources of biologically active natural products. These natural products have been thought to be produced by symbiotic bacteria in the marine sponges because structural frameworks of some natural products resemble those derived from terrestrial bacteria. However, there are few evidence that natural products are really produced by symbiotic bacteria since they are unculturable. In this project, we are searching compounds, which enhance cell growth, from the host sponge (Halicondria okadai) or another symbiont. In the related project, we isolated five novel cyclic peptides from marine-derived Streptomyces sp. JAMM992 and determined their structures including absolute configurations. Preliminary experiment implied that these peptides interacted one protein involving in cell growth of Streptomyces species.