Development of Novel Chip for Isolation of Circulating Tumor Cells Using Size-Selection and Photochemical Reaction

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The isolation of circulating tumor cells (CTCs) is expected toearly-diagnosis and tailor-made care of cancer. However, although the detection of CTCs was reported, the collection of living CTCs have been not realized. In this project, we developed microfluidic device composed of size-selection andIgG-coated photoreactive silicon device. This photoreactive IgG-coated silicon device can capture the target cells from cell-mixture and collect the living target cells by photoirradiation.