Search for anti-aging compounds from medicinal flowers

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We have researched anti-aging compounds from medicinal flowers. As the results, several constituents and its derivatives (oleanane-type triterpene saponins, benzylisoquinoline alkaloids, acylated quinic acids, lignans, and flavonoids) from the flower buds or/and flowers of Camellia japonica, Nelumbo nucifera, Prunus mume, Cananga odorata, and Lawsonia inermis were found to show inhibitory effects on melanogenesis in theophylline-stimulated B16 melanoma 4A5 cells. Furthermore, the inhibitory effects of the related compounds on melanogenesis were examined and their structure-activity relationships were characterized. In addition, we clarified a part of the mechanism of actions of nuciferin, which was the main compound of the flower buds of N. nucifera, on melanogenesis.