Development of Novel Chemoenzymatic Reaction System for OrganicSynthesis UtilizingIonic Polymers

利用功能化聚合物提供的新型反应介质通常可以为试剂或催化剂回收系统的设计带来新的策略。本文主要研究了利用离子丙烯酰胺基聚合物设计新型化学酶合成体系。在离子丙烯酰胺基聚合物溶液或聚合物凝胶中，脂肪酶催化的酯化反应进行顺利，具有较高的立体选择性。此外，这些酶可以很容易地与离子聚合物一起回收，并且在没有明显的催化活性损失的情况下被重复使用。

The use of a novel reaction medium provided by functionalized polymers could often bring a new strategy in the design of reagent or catalyst recycling systems. This work focused on the use of ionicacrylamide-based polymer for the design of novel chemoenzymaticreaction system. The lipase-catalyzed esterification reactions proceeded smoothly with high stereoselectivitiesin ionicacrylamide-based polymer solution or polymer gel. In addition, the enzymes can be easily recovered together with this ionic polymer and was reused without significant loss of catalytic activities.