Role of Nrf2-ARE pathway in dopaminergic neuronal death: identification of a novel activator

Nrf 2-ARE通路是一种抗氧化应激的细胞防御系统。该途径的激活增加了抗氧化酶的表达。在中脑培养物中，2′，3 ′-二羟基-4 ′，6 ′-二甲氧基查耳酮（DDC），一种来源于紫苏的绿色途径激活剂，可提高星形胶质细胞抗氧化酶的表达。DDC虽然不能诱导多巴胺能神经元抗氧化酶的表达，但多巴胺能神经元通过接受星形胶质细胞提供的抗氧化剂而获得对氧化应激的抵抗。

The Nrf2-ARE pathway is a cellular defense system against oxidative stress. Activation of this pathway increases expression of antioxidant enzymes. In mesencephalic cultures, 2′,3′-dihydroxy-4′,6′-dimethoxychalcone (DDC), a green perilla-derived activator of the pathway , elevated expression of antioxidant enzymes in astrocytes. Although DDC failed to induce the expression of antioxidant enzymes in dopaminergic neurons, dopaminergic neurons gained resistance to oxidative stress byreceiving the supply of antioxidants from astrocytes.