Study on nutritional signalings regulating the intestinal organelles in C. elegans

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The granular organelles that fill the C. elegans intestinal cells at the young adult stage deteriorate rapidly by food deprivation. This phenomenon also occurs in the mutant worms defective of the lysosome formation, suggesting that the deterioration is not dependent on autophagy and lysosome. The analyses of the nutritional signalings regulating the organelle revealed that the organelle requires a heat-labile hydrophobic nutrient for its formation and/or maintenance, and that the insulin/insulin-like growth factor signaling modulates the organelle. Furthermore, the multiple genetic factors regulating the formation, maintenance and/or deterioration of the organelle were identified by genetic screening using the RNA interference technique.