Association between siderophores produced by pathogenic vibrios and host inflammatory response

铁是细菌生存的必需元素，它的获得对于大多数病原菌在宿主内建立和维持感染的能力至关重要。副溶血性弧菌（Vibrio parahaemolyticus）是一种引起人类水样腹泻的病原菌，它能产生铁载体（Vibrioferrin），铁载体是由微生物产生的一种低分子量的铁结合螯合剂，并能从铁-铁载体复合物中获得铁。在这项研究中，我澄清了一个新的生产vibrioferrin的调节系统。此外，我检查了Vibrioferrin对宿主细胞的生理功能，并评估了参与Vibrioferrin生产的基因缺失对副溶血性弧菌细胞毒性的影响。

Iron is an essential element for bacterial survival, and its acquisition is crucial for the ability of most pathogenic bacteria to establish and maintain an infection within the host. Vibrio parahaemolyticus, a human pathogen causing watery diarrhea, can produce vibrioferrin, a type of siderophore which is a low-molecular-weight iron-binding chelator produced by microbes, and can acquire iron provided by iron-vibrioferrin complex. In this study, I clarified a novel regulatory system for production of vibrioferrin. Moreover, I examined a physiological function of vibrioferrin against host cells, and also assessed the influence of the deletion of gene involved in vibrioferrin production on cytotoxicity of V. parahaemolyticus.