Molecular mechanism of CYP1A2 gene expression in male regulated bygrowth hormone for personalized medicine

个体化用药男性生长激素调节CYP1A2基因表达的分子机制

• 批准号: 23790177
• 负责人: KAWASAKI Yuki
• 金额: $ 2.58万
• 依托单位: University of Toyama
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23790177/
• 关键词: CYP1A2; 遺伝子発現制御; 性差; 遺伝子発現調節; 転写因子

To clarify the molecular mechanism regulating the CYP1A2 sex-specific expression, the effect of the growth hormone was examined. The continuous females specific growth hormone pattern treatment led the decreased CYP1A2 mRNA expression in the hepatocytes. The binding of Fra1 and C/EBPα to the Cyp1a2 gene 5’-flanking region was revealed.

为了阐明调节CYP 1A 2性别特异性表达的分子机制，检查了生长激素的作用。持续雌性特异性生长激素模式处理导致肝细胞CYP 1A 2 mRNA表达降低。Fra 1和C/EBPα与Cyp 1a 2基因5 '侧翼区结合。

项目成果

Constitutive androstane receptor リガンド誘導性発現調節を担うマウスCyp1a2遺伝子の5’-上流域

小鼠 Cyp1a2 基因的 5-上游区域负责调节配体诱导的组成型雄甾烷受体的表达

• 作者: 河崎優希;古野幸美;後藤雄真;佐久間勉;櫻井宏明;根本信雄
• 通讯作者: 根本信雄