The analysis of urinary tract formation; a new approach focused on the developmental role of cloaca during embryogenesis

尿路形成分析；

• 批准号: 23790228
• 负责人: HARAGUCHI Ryuma
• 金额: $ 2.25万
• 依托单位: Ehime University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23790228/
• 关键词: 泌尿生殖器; 平滑筋; 組織系譜解析

Congenital diseases of the urinary tract are frequently observed in infants. Such diseases present a number of developmental anomalies such as hydroureter and hydronephrosis. Although some genetically-modified mouse models of growth factor signaling genes reproduce urinary phenotypes, the pathogenic mechanisms remain obscure. Previous studies suggest that a portion of the cells in the external genitalia and bladder are derived from peri-cloacal mesenchymal cells that receive Hedgehog (Hh) signaling in the early developmental stages. We hypothesized that defects insuch progenitor cells, which give rise to urinary tract tissues, may be a cause of such diseases. Our study identified the essential embryonic stages for the pathogenesis of urinary tract phenotypes. These results suggested that Hh-responsive mesenchymal Bmp signaling maintains the population of peri-cloacal mesenchyme cells, which is essential for the development of the ureter and the upper urinary tract.

尿路的先天性疾病经常在婴儿中观察到。这些疾病呈现出许多发育异常，例如水力器和肾结通。尽管某些遗传修饰的生长因子信号基因的小鼠模型可再现尿液表型，但致病机制仍然晦涩。先前的研究表明，外生殖器和膀胱中的一部分细胞源自在早期发育阶段接收刺猬（HH）信号传导的羊皮周期间充质细胞。我们假设存在导致尿路组织的缺陷祖细胞可能是这种疾病的原因。我们的研究确定了尿路表型发病机理的必需胚胎阶段。这些结果表明，HH响应性间充质BMP信号传导维持羊皮周期间充质细胞的种群，这对于输尿管和上尿路的发育至关重要。

项目成果

新規遺伝子改変マウスを用いた平滑筋組織の機能破綻に起因する腎尿路疾患についての解析

新型转基因小鼠分析平滑肌组织功能障碍引起的肾脏和泌尿道疾病

• 发表时间: 2011
• 作者: 原口竜摩;松丸大輔;杉田敦郎;木藤克己;阿部康人;北澤理子;山田 源;北澤荘平
• 通讯作者: 北澤荘平

愛媛大学大学院医学系研究科 愛媛大学医学部

爱媛大学医学研究科 爱媛大学医学部

Pulmonary hypertension associated with diffuse deposition of pentosidine in pulmonary arterioles

• DOI: 10.1016/j.diabres.2013.01.019
• 发表时间: 2013-05-01
• 期刊: DIABETES RESEARCH AND CLINICAL PRACTICE
• 影响因子: 5.1
• 作者: Komoda, Munenori;Kitazawa, Riko;Kitazawa, Sohei
• 通讯作者: Kitazawa, Sohei

The hedgehog signal induced modulation of bone morphogenetic protein signaling: an essential signaling relay for urinary tract morphogenesis.

• DOI: 10.1371/journal.pone.0042245
• 发表时间: 2012
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Haraguchi R;Matsumaru D;Nakagata N;Miyagawa S;Suzuki K;Kitazawa S;Yamada G
• 通讯作者: Yamada G

愛媛大学大学院医学系研究科 分子病理学講座

爱媛大学医学研究科分子病理学系