The analysis for sex difference of somatic cells via DM-domain related transcription factors

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It has been reported that DM-domain transcription factor, DMRT, gives sex difference through regulating the development of male sex organ. We studied whether the DMRT express in other somatic cells and give sex difference. Expression of DMRT genes was observed several organs in mice, moreover, sex-specific expression of DMRT genes were observed in heart. In addition, we observed that DMRT2 suppresses cell proliferation of MCF-7, breast cancer cell line. These results suggest that DMRT genes have physiological functionin somatic tissues except for sex organs.