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Novel mechanisms of macrophage regulation by u-PA/plasmin system during liver repair

Novel mechanisms of macrophage regulation by u-PA/plasmin system during liver repair
u-PA/纤溶酶系统在肝脏修复过程中调节巨噬细胞的新机制
批准号:
23790260
负责人:
KAWAO Naoyuki
金额:
$2.75万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012

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中文摘要
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英文摘要
We investigated novel mechanisms of macrophage regulation by u-PA/plasmin system during liver repair. Our study indicates that u-PA/plasmin system is essential for liver repair through triggering macrophage accumulation at the border region of damaged site. Moreover, u-PA/plasmin system mediates the induction of phenotypic heterogeneity, cell polarity, and phagocytosis of necrotic tissue in the accumulated macrophages by its influence of the surrounding microenvironment at the edge of damaged tissue during liver repair.
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DOI: 10.1160/th10-08-0516
发表时间: 2011-05-01
期刊: THROMBOSIS AND HAEMOSTASIS
影响因子: 6.7
作者: [Kawao, Naoyuki, Nagai, Nobuo, Matsuo, Osamu]
通讯作者: Matsuo, Osamu
Impaired accumulation of macrophages and absence of their phenotype heterogeneity during liver repair in urokinase-deficient mice.
尿激酶缺陷小鼠肝脏修复过程中巨噬细胞积累受损且缺乏表型异质性。
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [Kawao N, Nagai N, Tamura Y, Okumoto K, Okada K, Yano M, Suzuki Y, Umemura K, Ueshima S, Matsuo O.]
通讯作者: Matsuo O.
Macrophages are regulated by urokinase-type plasminogen activator during liver repair
肝脏修复过程中巨噬细胞受到尿激酶型纤溶酶原激活剂的调节
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [福島 篤, 舩橋 利也, 明間 立雄, 河尾直之,永井信夫,田村行識,堀内喜高,奥本勝美,岡田清孝,矢野昌人,鈴木康裕,梅村和夫,梶 博史,松尾 理, 目崎喜弘, 榎木亮介,黒田茂,小野大輔,Hasan Mazahir,上田哲男,本間さと,本間研一, 河尾直之,永井信夫,田村行識,奥本勝美,岡田清孝,矢野昌人,鈴木康裕,梅村和夫,梶 博史,松尾 理, 目崎喜弘 ほか, 河尾直之,永井信夫,田村行識,奥本勝美,鈴木康裕,梅村和夫,岡田清孝,矢野昌人,梶 博史,松尾 理]
通讯作者: 河尾直之,永井信夫,田村行識,奥本勝美,鈴木康裕,梅村和夫,岡田清孝,矢野昌人,梶 博史,松尾 理
肝障害部位へのマクロファージの集積および活性化におけるu-PAの役割
u-PA 在肝损伤部位巨噬细胞积聚和激活中的作用
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [河尾直之, 永井信夫,田村行識,奥本勝美,岡田清孝,矢野昌人,鈴木康裕,梅村和夫,梶 博史,松尾 理]
通讯作者: 永井信夫,田村行識,奥本勝美,岡田清孝,矢野昌人,鈴木康裕,梅村和夫,梶 博史,松尾 理
14
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