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To reveal a cause of development of hypertension with long term measurement of sympathetic nerve activity

通过长期测量交感神经活动揭示高血压发生的原因

基本信息

批准号：
23790285
负责人：
YOSHIMOTO Misa
金额：
$ 2.83万
依托单位：
National Cardiovascular Center Research Institute
依托单位国家：
日本
项目类别：
Grant-in-Aid for Young Scientists (B)
财政年份：
2011
资助国家：
日本
起止时间：
2011 至 2013
项目状态：
已结题

项目摘要

Hypertension is a disease. One in four adults in the world have been diagnosed with high blood pressure. The aim of the present study was to explore a potential role of sympathetic nerve activity in the initial development of hypertension. The aim of the present study was to explore a potential role of sympathetic nerve activity in the initial development of hypertension. Salt sensitive hypersensitive rats and stroke-prone spontaneously hypertensive rats were used this experiments. The rats were chronically instrumented with a bipolar electrode for measurements of renal (RSNA) and lumbar sympathetic nerve activity (LSNA) and telemeter for measurements of arterial pressure (AP) and heart rate (HR). RSNA and LSNA apparently did not increase while development of hypertension occurred. It is therefor likely that possible contribution of sympathetic nerve activity to the initial development of hypertension in those hypersensitive rats remains uncertain.

高血压是一种疾病。世界上四分之一的成年人被诊断患有高血压。本研究的目的是探讨交感神经活动在高血压初期发展中的潜在作用。本研究的目的是探讨交感神经活动在高血压初期发展中的潜在作用。本实验使用盐敏感性超敏大鼠和易发生中风的自发性高血压大鼠。大鼠长期使用双极电极测量肾脏（RSNA）和腰交感神经活动（LSNA），并使用遥测仪测量动脉压（AP）和心率（HR）。当高血压发生时，RSNA和LSNA显然没有增加。因此，交感神经活动对这些过敏大鼠高血压最初发展的可能贡献仍不确定。