the role of renal tubular p21 in diabetic nephropathy

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We examined the role of renal senescence in the diabetic kidney. The animal models of diabetes (either type 1 or 2) showed early-onset and time-dependently increased renal senescence through p21-dependent pathway in proximal tubular cells. The senescent diabetic kidney had an increase in TNF-α and immune cells infiltration. The treatment of diabetes reversed the senescent kidney into normal. The results suggest that renal senescence is treatable and could be a new target of diabetic nephropathy.