ATP/adenosine as a critical link between altered metabolism and neuronal activity

ATP/腺苷是代谢改变和神经元活动之间的关键联系

• 批准号: 23790303
• 负责人: KAWAMURA Masahito
• 金额: $ 2.83万
• 依托单位: Jikei University School of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23790303/
• 关键词: アデノシン受容体; ケトン食療法; てんかん; 薬理学; 神経科学

The “cause-and-effect” relationship between altered metabolism and the neurological conditions are not fully understood yet. We hypothesized that ATP/adenosine might play a specific role in modulating neuronal activity to produce the anticonvulsant effects of the ketogenic diet. We found that ketogenic diet-induced antiseizure effect is caused by ATP release with the subsequent activation of adenosine A_1 receptors.

新陈代谢改变和神经系统疾病之间的“因果关系”还没有被完全理解。我们假设ATP/腺苷可能在调节神经元活动中发挥特定作用，从而产生生酮饮食的抗惊厥作用。我们发现生酮饮食诱导的抗癫痫作用是由ATP释放引起的，随后腺苷A_1受体被激活。

项目成果

アデノシン受容体の活性化を介した海馬アストロサイト自発的カルシウム・オシレーション頻度の長期増強

通过激活腺苷受体长期增强海马星形胶质细胞自发钙振荡频率

• 发表时间: 2011
• 作者: N.Ikarashi;R.Kon;T.Iizasa;N.Suzuki;R.Hiruma;K.Suenaga;T.Toda;M.Ishii;M.Hoshino;W.;今西正樹;川村将仁
• 通讯作者: 川村将仁

A ketogenic diet delays weight loss and does not impair working memory or motor function in the R6/2 1J mouse model of Huntington's disease.

• DOI: 10.1016/j.physbeh.2011.04.001
• 发表时间: 2011-07-06
• 期刊: PHYSIOLOGY & BEHAVIOR
• 影响因子: 2.9
• 作者: Ruskin, David N.;Ross, Jessica L.;Kawamura, Masahito, Jr.;Ruiz, Tiffany L.;Geiger, Jonathan D.;Masino, Susan A.
• 通讯作者: Masino, Susan A.

Metabolism and Purinergic Autocrine Regulation. (ワークショップ)

代谢和嘌呤能自分泌调节（研讨会）

• 发表时间: 2012
• 作者: Kawamura M;Jr.
• 通讯作者: Jr.

Adenosine and autocrine metabolic regulation of neuronal activity. In:Adenosine: a Key Link between Metabolism and CNS Activity (Masino SA, Boison D, eds)

腺苷和神经元活动的自分泌代谢调节。

• 发表时间: 2012
• 作者: Kawamura M;Jr.;Ruskin DN
• 通讯作者: Ruskin DN

Adenosine-mediated inhibition of excitatory transmission during ischemia at different temperatures in the hippocampus.

不同温度下海马缺血期间腺苷介导的兴奋性传递抑制。

• 发表时间: 2013
• 作者: M. Kutsukake;M. Kobayashi;K. Tamura;M.Yoshie;E. Tachikawa;A. Matsuda;E. Uchida,and T. Matsutani;Kawamura M
• 通讯作者: Kawamura M