Significance of the interferon signal regulation in the maintenance of tissue stem cells

在这项研究中，我研究了干扰素信号调节在表皮干细胞（EpSCs）维持中的意义。因此，我们发现，与对照小鼠相比，缺乏IRF2（一种i型IFN信号的生理衰减剂）的小鼠，EpSCs的数量随着年龄的增长而减少。结合谱系追踪研究的结果，我们预计在过度IFN信号传导的环境中，EpSCs的过早分化是被促进的。

In this study, I examined the significance of the interferon signal regulation in the maintenance of epidermal stem cells (EpSCs). As a result, we found that the mice deficient for IRF2, which is a physiological attenuator of type-I IFN signaling, the number of EpSCs decreased with aging in comparison with a control mouse. Combined with the results from lineage tracing studies, it was expected that the premature differentiation of EpSCs was promoted in the environments of excessive IFN signaling.