Significance of the interferon signal regulation in the maintenance of tissue stem cells

干扰素信号调节在组织干细胞维持中的意义

• 批准号: 23790326
• 负责人: SATO Taku
• 金额: $ 2.83万
• 依托单位: Tokyo Medical and Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23790326/
• 关键词: 幹細胞性; インターフェロン; 造血幹細胞; 表皮幹細胞; 幹細胞

In this study, I examined the significance of the interferon signal regulation in the maintenance of epidermal stem cells (EpSCs). As a result, we found that the mice deficient for IRF2, which is a physiological attenuator of type-I IFN signaling, the number of EpSCs decreased with aging in comparison with a control mouse. Combined with the results from lineage tracing studies, it was expected that the premature differentiation of EpSCs was promoted in the environments of excessive IFN signaling.

在这项研究中，我研究了干扰素信号调节在表皮干细胞（EpSCs）维持中的意义。因此，我们发现，与对照小鼠相比，缺乏IRF2（一种i型IFN信号的生理衰减剂）的小鼠，EpSCs的数量随着年龄的增长而减少。结合谱系追踪研究的结果，我们预计在过度IFN信号传导的环境中，EpSCs的过早分化是被促进的。

项目成果

Novel interferon (IFN)-based pre-transplantation conditioning in the treatment of congenital metabolic disorder

基于新型干扰素（IFN）的移植前调理治疗先天性代谢紊乱

• 发表时间: 2011
• 作者: Taku Sato;Satoshi Yotsumoto;Toshiaki Ohteki
• 通讯作者: Toshiaki Ohteki