The neural circuit for dopaminergic system regulation by Notch signaling

Notch信号传导调节多巴胺能系统的神经回路

• 批准号: 23790350
• 负责人: TANIGAKI Kenji
• 金额: $ 2.75万
• 依托单位: 滋賀県立成人病センター研究所 (2012)Research Institute, Shiga Medical Center (2011)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23790350/
• 关键词: 高次生命医学; Notch; active avoidance; neuron; RBP-J; striatum; instrumental learning; 転写因子

Notch/RBP-J signaling regulates neural development at multiple stages. We utilized RBP-J conditional knockout mice and found that neuron-specific loss of RBP-J, a main mediator of Notch signaling, causes the deficits in the dopaminergic responsiveness. To elucidate which neural circuit is responsible for Notch -dependent control of Dopaminergic signaling, we examined the sites of Notch signaling activation in the central nervous system.

Notch/RBP-J信号在多个阶段调节神经发育。我们利用RBP-J条件性基因敲除小鼠，发现神经元特异性的RBP-J（Notch信号传导的主要介质）缺失导致多巴胺能反应性的缺陷。为了阐明哪种神经回路负责Notch依赖的多巴胺能信号传导控制，我们检查了中枢神经系统中Notch信号传导激活的位点。

项目成果

Rescue of behavioral abnormalitie s of 22g11.2 deletion syndrome mo del mice by prefrontal cortex-spe cific COMT overexpression

前额皮质特异性 COMT 过表达对 22g11.2 缺失综合征模型小鼠行为异常的拯救

• 发表时间: 2012
• 作者: Ishifune C;et al;Kenji Tanigaki
• 通讯作者: Kenji Tanigaki

Neuropathological analysis of 22q 11.2 deletion syndrome model mice

22q 11.2缺失综合征模型小鼠神经病理学分析

• 发表时间: 2011
• 作者: Ishifune C;et al;Kenji Tanigaki;Kenji Tanigaki;Kenji Tanigaki;谷垣健二
• 通讯作者: 谷垣健二

Notch signaling regulates nucleocyt oplasmic Olig2 translocation in rea ctive astrocytes differentiation of ter ischemic stroke

Notch信号调节缺血性中风反应性星形胶质细胞分化中核细胞质Olig2易位

• 发表时间: 2013
• 期刊: Neurosci Res
• 影响因子: 2.9
• 作者: Marumo T;Takagi Y;Muraki K;Hashi moto N;Miyamoto S;Tanigaki K
• 通讯作者: Tanigaki K

Notch signaling regulates nucleocytoplasmic Olig2 translocation in reactive astrocytes differentiation after ischemic stroke

• DOI: 10.1016/j.neures.2013.01.006
• 发表时间: 2013-03-01
• 期刊: NEUROSCIENCE RESEARCH
• 影响因子: 2.9
• 作者: Marumo, Takeshi;Takagi, Yasushi;Tanigaki, Kenji
• 通讯作者: Tanigaki, Kenji

Neuropathological analysis of 22q11.2 deletion syndrome model mice

22q11.2缺失综合征模型小鼠神经病理学分析

• 发表时间: 2011
• 作者: Ishifune C;et al;Kenji Tanigaki;Kenji Tanigaki
• 通讯作者: Kenji Tanigaki