Research on geographical origin and spread of drug resistant Plasmodium vivax in Asia

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Genetic polymorphisms of chloroquine (CQ) resistant gene and the polymorphisms flanking the gene of Plasmodium vivax in Asia were examined. All the isolates from the Philippines where treatment failure to CQ had never been reported possessed resistant genotype. On the other hand, all the isolates from the Republic of Korea where treatment failure to CQ had been reported possessed susceptible genotype. These results suggested that the polymorphisms of the resistant gene were local genotypes and that the association between the genotypes and CQ susceptibility were elusive.