Characterization of intestinal microbiota for the treatment of inflammatory bowel disease

用于治疗炎症性肠病的肠道微生物群特征

• 批准号: 23790524
• 负责人: ATARASHI Koji
• 金额: $ 2.75万
• 依托单位: The Institute of Physical and Chemical Research (2012)The University of Tokyo (2011)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23790524/
• 关键词: 制御性T 細胞; 腸内細菌; 炎症性腸疾患; Treg; Clostridium; IL-10; 腸管免疫; 制御性T細胞

Many studies suggest that altered intestinal microbiota may play a major role in the onset and exacerbation of several inflammatory diseases, including inflammatory bowel diseases (IBDs). We previously reported that murine commensal bacteria Clostridium spp. have the capacity to induce intestinal regulatory T (Treg) cells. This study was focused on the human intestinal bacteria which can induce Treg cells in the intestine. I successfully isolated the bacteria with the ability to induce Treg cells from human stool, and administration of these bacteria attenuated disease in models of colitis and allergic diarrhea.

许多研究表明，肠道微生物区系改变可能在几种炎症性疾病的发生和加重中发挥重要作用，包括炎症性肠病(IBDS)。我们先前报道了小鼠共生菌Clostridium spp.具有诱导肠道调节性T(Treg)细胞的能力。本研究主要针对能在肠道内诱导Treg细胞的人体肠道细菌进行研究。我成功地从人类粪便中分离出了能够诱导Treg细胞的细菌，并服用这些细菌减轻了结肠炎和过敏性腹泻模型中的疾病。

项目成果

Human clostridium species promote intestinal accumulation of Treg cells

人类梭菌促进 Treg 细胞肠道积聚

• 发表时间: 2013
• 作者: Kobiyama K;Aoshi T;Ishii KJ.;Atarashi K
• 通讯作者: Atarashi K

Induction of colonic regulatory T cells by indigenous Clostridium species.

• DOI: 10.1126/science.1198469
• 发表时间: 2011-01-21
• 期刊: Science (New York, N.Y.)
• 作者: Atarashi K;Tanoue T;Shima T;Imaoka A;Kuwahara T;Momose Y;Cheng G;Yamasaki S;Saito T;Ohba Y;Taniguchi T;Takeda K;Hori S;Ivanov II;Umesaki Y;Itoh K;Honda K
• 通讯作者: Honda K

炎症と免疫

炎症和免疫

• 发表时间: 2021
• 作者: Hatano Jiro;Kusama Shoko;Tanaka Kenya;Kohara Ayaka;Miyake Chikahiro;Nakanishi Shuji;Shimakawa Ginga;長井 志江;小松紀子
• 通讯作者: 小松紀子

Composition for inducing proliferation or accumulation of regulatory t cells

用于诱导调节性T细胞增殖或积累的组合物

• 发表时间: 2011

腸内細菌によるT 細胞応答の誘導

肠道细菌诱导 T 细胞反应

• 发表时间: 2013
• 作者: Nakayama;T.;and Onodera;A.;新幸二
• 通讯作者: 新幸二