Characterization of intestinal microbiota for the treatment of inflammatory bowel disease

许多研究表明，肠道微生物群的改变可能在包括炎症性肠病（IBDs）在内的几种炎症性疾病的发病和恶化中发挥重要作用。我们之前报道了小鼠共生细菌梭状芽胞杆菌具有诱导肠道调节性T （Treg）细胞的能力。本研究的重点是在肠道中诱导Treg细胞的人肠道细菌。我成功地从人类粪便中分离出具有诱导Treg细胞能力的细菌，并在结肠炎和过敏性腹泻模型中施用这些细菌减轻了疾病。

Many studies suggest that altered intestinal microbiota may play a major role in the onset and exacerbation of several inflammatory diseases, including inflammatory bowel diseases (IBDs). We previously reported that murine commensal bacteria Clostridium spp. have the capacity to induce intestinal regulatory T (Treg) cells. This study was focused on the human intestinal bacteria which can induce Treg cells in the intestine. I successfully isolated the bacteria with the ability to induce Treg cells from human stool, and administration of these bacteria attenuated disease in models of colitis and allergic diarrhea.