Thymic Sirpα^<+>DC subset conducts the novel process of intrathymic immune tolerance
Thymic Sirpα^<+>DC subset conducts the novel process of intrathymic immune tolerance
批准号:
23790532
负责人:
BABA Tomohisa
金额:
$2.75万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012
中文摘要
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英文摘要
The discrimination of self or non-self antigens is essential for the maintenance of intact immune system. In this study, we demonstrated that a thymic dendritic cell (DC) subset, Sirpα+ DC is the major conductor of the novel process of intrathymic immune tolerance against blood-borne antigens. Moreover, the secretory tumor-specific antigens can induce the intrathymic anti-tumor immune tolerance through the antigen presentation by thymic Sirpα+ DCs.
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Intrathymic perivascular dendritic cells capturing blood-borne antigens conduct central tolerance
胸腺内血管周围树突状细胞捕获血源性抗原进行中枢耐受
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[渡士幸一, 内田奈々子, 大東卓史, 清原知子, 鈴木亮介, 相崎英樹, 脇田隆字, 馬場 智久]
通讯作者:
馬場 智久
DOI:
10.1016/j.ajpath.2011.11.012
发表时间:
2012-03-01
期刊:
AMERICAN JOURNAL OF PATHOLOGY
影响因子:
6
作者:
[Tomaru, Utano, Takahashi, Satomi, Kasahara, Masanori]
通讯作者:
Kasahara, Masanori
Intrathymic perivascular dendritic 図2 血中抗原に対するcentral toleranceの誘導 cells capturing blood-borne antigens conduct central tolerance
胸腺内血管周围树突 图2 血源性抗原中枢耐受的诱导 捕获血源性抗原的细胞进行中枢耐受
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[馬場智久, 向田直史]
通讯作者:
向田直史
Establishment of CML mouse model to examine the interactive role of normal hematopoietic system on the pathophysiology
建立慢性粒细胞白血病小鼠模型,探讨正常造血系统在病理生理学中的相互作用
DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[Tezuka, H., 馬場 智久]
通讯作者:
馬場 智久
Novel process of intrathymic immune tolerance against secretory tumorspecific antigens
针对分泌性肿瘤特异性抗原的胸腺内免疫耐受的新过程
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[馬場智久, 向田直史]
通讯作者:
向田直史
共 8 条
Pathophysiological role of inflammatory chemokine, CCL3, in chronic myeloid leukemia
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批准号:16K08733
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.16万
-
财政年份:2016
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负责人:BABA Tomohisa
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依托单位:
Research of biological function and distinctive role of Sirp・^+ dendritic cells in central tolerance
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批准号:21790464
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.75万
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财政年份:2009
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负责人:BABA Tomohisa
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依托单位:
The cytotoxic mechanism and immunological role of CD4+CD8+ macrophages
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批准号:19890081
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项目类别:Grant-in-Aid for Young Scientists (Start-up)
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资助金额:$1.97万
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财政年份:2007
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负责人:BABA Tomohisa
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依托单位:
海外基金