Role of prostaglandin E2 in the development of cancer chemotherapeutic agents-induced side effects

临床报告表明，许多接受癌症化疗和手术的患者在全身麻醉下发生恶心和呕吐。然而，这些症状的确切病因尚不清楚。为了阐明其可能的机制，我们试图建立大鼠恶心呕吐动物模型，并研究了大鼠恶心呕吐发生的相关神经递质。通过一系列的实验，我们证实异食癖，高岭土摄食行为，有助于评估大鼠的恶心和呕吐，前列腺素E2， P物质和白三烯可能有助于发展。

Clinical reports demonstrated that nausea and vomiting occurs in many patients receiving cancer chemotherapy and surgery under general anesthesia. However, precise etiology of these symptoms are still unclear. To elucidate a possible mechanism, we tried to make an animal model of nausea and vomiting in rats and investigated the responsible neurotransmitters attributed to development of nausea and vomiting in rats. From a series of experiments, we confirmed that pica, kaolin ingestion behavior, is useful to evaluate nausea and vomiting in rats and prostaglandin E2, substance P and leukotriene may contribute to the development.