Role of prostaglandin E2 in the development of cancer chemotherapeutic agents-induced side effects

前列腺素 E2 在癌症化疗药物引起的副作用发生中的作用

• 批准号: 23790598
• 负责人: YAMAMOTO Kouichi
• 金额: $ 2.75万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23790598/
• 关键词: 悪心・嘔吐; 発症機構; プロスタグランジン; サブスタンスP; ロイコトリエン; プロスタグランジンE2; アラキドン酸カスケード; 抗癌剤; 有害反応; 抗癌剤誘発有害反応; 倦怠感; 食欲不振; 腫瘍壊死因子（TNF）-α; シスプラチン; プロスタグランジン（PG）E2; 悪心; シクロオキシゲナーゼ（COX）-2; ドセタキセル

Clinical reports demonstrated that nausea and vomiting occurs in many patients receiving cancer chemotherapy and surgery under general anesthesia. However, precise etiology of these symptoms are still unclear. To elucidate a possible mechanism, we tried to make an animal model of nausea and vomiting in rats and investigated the responsible neurotransmitters attributed to development of nausea and vomiting in rats. From a series of experiments, we confirmed that pica, kaolin ingestion behavior, is useful to evaluate nausea and vomiting in rats and prostaglandin E2, substance P and leukotriene may contribute to the development.

临床报告显示，许多在全身麻醉下接受癌症化疗和手术的患者会发生恶心和呕吐。然而，这些症状的确切病因尚不清楚。为了阐明一个可能的机制，我们试图在大鼠中建立恶心和呕吐的动物模型，并研究引起大鼠恶心和呕吐的神经递质。通过一系列的实验，我们证实了异食癖，高岭土的摄入行为，是有用的评估恶心和呕吐的大鼠和前列腺素E2，P物质和白三烯可能有助于发展。

项目成果

In vivo monitoring of cisplatin-induced substance P release in the medulla of rats measured by brain microdialysis.

通过脑微透析测量顺铂诱导的大鼠髓质 P 物质释放的体内监测。

• 发表时间: 2013
• 作者: Kouichi Yamamoto;Ayana Tasaka;Seikou Kim;Yui Ito;Atsushi Yamatodani
• 通讯作者: Atsushi Yamatodani

nvolvement of medullary substance P in the development of cisplatin-induced emesis in rats

髓质P物质在顺铂诱导大鼠呕吐发生中的作用

• 发表时间: 2013
• 作者: 山本浩一;田坂礼那;金世洸;大和谷厚
• 通讯作者: 大和谷厚

Involvement of substance P in the development of cisplatin-induced acute and delayed pica in rats

• DOI: 10.1111/bph.12629
• 发表时间: 2014-06-01
• 期刊: BRITISH JOURNAL OF PHARMACOLOGY
• 影响因子: 7.3
• 作者: Yamamoto, Kouichi;Asano, Keiko;Yamatodani, Atsushi
• 通讯作者: Yamatodani, Atsushi

Involvement of hypothalamic cyclooxygenase-2, interleukin-1β and melanocortin in the development of docetaxel-induced anorexia in rats.

• DOI: 10.1016/j.tox.2012.07.015
• 发表时间: 2012-12
• 期刊: Toxicology
• 影响因子: 4.5
• 作者: Kouichi Yamamoto;Keiko Asano;Yui Ito;N. Matsukawa;Sei-Gun Kim;A. Yamatodani

The effects of celecoxib on chemotherapy-related fatigue in mice

塞来昔布对小鼠化疗相关性疲劳的影响

• 发表时间: 2012
• 作者: 松川直樹;山本浩一;後藤飛鳥;大和谷厚
• 通讯作者: 大和谷厚