Comprehensive analysis of genetic abnormalities in gastrointestinal cancers and the identification of molecular targeted therapy targeting those alterations

由于许多国家的人口老龄化，预计老年结直肠癌（CRC）患者的数量将增加。美国和欧洲国家的研究表明，老年CRC患者的临床和分子特征为女性、右侧结肠、BRAF突变、MLH1甲基化和微卫星不稳定性（microsatellite instability， MSI），且这些CRC的前体病变呈现锯齿状病变。就日本而言，人口老龄化的速度比其他任何国家都快得多；然而，在大量日本老年患者中，尚无关于crc和锯齿状病变特征的研究。因此，我们进行了一项回顾性的大规模日本队列研究，并检查了老年患者的临床病理和分子特征。

The number of elderly colorectal cancer (CRC) patients is expected to increase because of the aging populations in many countries. Previous studies in the U.S. and European countries have shown that the clinical and molecular features of elderly CRC patients were female, right-side colon, BRAF mutation, MLH1 methylation and microsatellite instability (MSI) and that the precursor lesions of those CRCs appeared to be serrated lesions. With regard to Japan, the population is aging much faster than that of any other countries; however, there has been no study on the characteristics of CRCs and serrated lesions in a large population of elderly Japanese patients. We therefore conducted a retrospective large-scale Japanese cohort study and examined the clinicopathological and molecular features of elderly patients.