Development of observational tool of the vascular lumen vessel wall of pulmonary artery lesion in patients with pulmonary hypertension.

肺动脉高压患者肺动脉病变血管腔血管壁观察工具的研制

• 批准号: 23790827
• 负责人: MIURA YUTAKA
• 金额: $ 2.66万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23790827/
• 关键词: 肺高血圧症; 血管内皮イメージ; 右心機能; 血管内イメージ

(1) OCT images of the pulmonary artery lesion in patients with pulmonary hypertension showed network-shaped web image in patients with chronic thromboembolic pulmonary hypertension (CTEPH).Percutaneous transluminal pulmonary angioplasty (PTPA) significantly improved symptom, BNP levels, pulmonary hemodynamics. Also, PTPA group had significantly better prognosis compared with historical group (P<0.05).(2) In pulmonary hypertension animal models, we examined the small pulmonary artery and pulmonary artery main trunk lesions, and the right ventricular (RV) function. RV remodeling occurs early in PH development through fibrosis, perivascular remodeling, capillary rarefaction and autophagy, for which eNOS pathway and collagen metabolism may be involved.

(1)慢性血栓栓塞性肺动脉高压（CTEPH）患者肺动脉病变OCT图像呈网状网状，经皮肺动脉腔内成形术（PTPA）治疗后症状、BNP水平、肺血流动力学均明显改善。PTPA组预后明显好于既往史组（P<0.05）。(2)在肺动脉高压动物模型中，我们检查了小肺动脉和肺动脉主干病变，以及右心室（RV）功能。RV重构在PH发展的早期通过纤维化、血管周围重构、毛细血管稀疏和自噬发生，其中可能涉及eNOS途径和胶原代谢。

项目成果

Three-dimensional-optical coherence tomography imaging of chronic thromboembolic pulmonary hypertension.

慢性血栓栓塞性肺动脉高压的三维光学相干断层扫描成像。

• DOI: 10.1093/eurheartj/eht203
• 发表时间: 2013
• 期刊: European Heart Journal.
• 作者: 中村徹、鳥村拓司;他;Shunsuke Tatebe;Koichiro Sugimura
• 通讯作者: Koichiro Sugimura

Usefulness of optical coherence tomography for diagnosis and treatment in chronic thromboembolic pulmonary hypertension

光学相干断层扫描在慢性血栓栓塞性肺动脉高压诊断和治疗中的应用

• 发表时间: 2013
• 作者: Sugimura Koichiro;Fukumoto Yoshihiro;Miura Yutaka;Nochioka Kotaro;Tatebe Shunsuke、Yamamoto Saori;Miura Masanobu;Satoh Kimio;Shimokawa Hiroaki
• 通讯作者: Shimokawa Hiroaki