Development of observational tool of the vascular lumen vessel wall of pulmonary artery lesion in patients with pulmonary hypertension.

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(1) OCT images of the pulmonary artery lesion in patients with pulmonary hypertension showed network-shaped web image in patients with chronic thromboembolic pulmonary hypertension (CTEPH).Percutaneous transluminal pulmonary angioplasty (PTPA) significantly improved symptom, BNP levels, pulmonary hemodynamics. Also, PTPA group had significantly better prognosis compared with historical group (P<0.05).(2) In pulmonary hypertension animal models, we examined the small pulmonary artery and pulmonary artery main trunk lesions, and the right ventricular (RV) function. RV remodeling occurs early in PH development through fibrosis, perivascular remodeling, capillary rarefaction and autophagy, for which eNOS pathway and collagen metabolism may be involved.