Interorgan communication between heart and kidney in the development of cardiorenal diseases

我们揭示了肾脏初始炎症的一种新机制。据报道，肾集合管上皮细胞是维持水平衡的关键细胞。除了这一基本功能外，我们还展示了集合管细胞通过从骨髓中招募炎性巨噬细胞进入肾脏而引起肾脏最初的炎症反应。在这个过程中，转录因子KLF5在集合管细胞中被激活，并分泌S100A8和S100A9，从而招募炎症细胞。

We revealed a novel mechanism of renal initial inflammation. Renal collecting duct epithelial cells have been reported as key cells in water homeostasis. In addition to this basic function, we showed collecting duct cells induced renal initial inflammation in response to renal injury by recruiting inflammatory macrophages into kidney from bone marrow. In this process, transcription factor KLF5 is activated in collecting duct cells and secretes S100a8 and S100a9 which can recruit inflammatory cells.