Adipocytokines and cardio-renal diseases

脂肪细胞因子与心肾疾病

• 批准号: 23790845
• 负责人: SHIBATA Rei
• 金额: $ 2.66万
• 依托单位: Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23790845/
• 关键词: 脂肪細胞由来因子; アディポネクチン; 心不全; 腎不全; サイトカイン; 敗血症; アディポサイトカイン; 慢性腎臓病

Adipose tissue functions as an endocrine organ by secreting adipocytokines that can directly affect nearby or remote organs. Adiponectin is an adipocytokine whose concentration is down-regulated in subjects with obesity-related disorders. Low levels of circulating adiponectin appear to associate with the increased prevalence of obesity-linked diseases including cardiac and renal dysfunction. In our study, we have shown that adiponectin exerts beneficial effects on the cardio-renal system by directly acting on the component cells in the heart and kidney. The cardiovascular protection by adiponectin is mediated through its ability to attenuate apoptotic activity in the target organs. Thus, adiponectin could represent a therapeutic target molecule for prevention or treatment of cardio-renal diseases.

脂肪组织是一种内分泌器官，其分泌的脂肪细胞因子可直接影响近端或远端器官。脂联素是一种脂肪细胞因子，其浓度在肥胖相关疾病患者中下调。低水平的循环脂联素似乎与肥胖相关疾病（包括心脏和肾脏功能障碍）的患病率增加有关。在我们的研究中，我们已经证明脂联素通过直接作用于心脏和肾脏的组成细胞对心肾系统产生有益的作用。脂联素的心血管保护作用是通过其减弱靶器官凋亡活性的能力来介导的。因此，脂联素可以作为预防或治疗心肾疾病的治疗靶分子。

项目成果

Therapeutic impact of follistatin-like 1 on myocardial ischemic injury in preclinical animal models

• 发表时间: 2012
• 作者: 小椋 康弘

Fat-derived Factor Omentin Stimulates Endothelial Cell Function and Ischemia-induced Revascularization via Endothelial Nitric Oxide Synthase-dependent Mechanism

• DOI: 10.1074/jbc.m111.261818
• 发表时间: 2012-01-02
• 期刊: JOURNAL OF BIOLOGICAL CHEMISTRY
• 影响因子: 4.8
• 作者: Maruyama, Sonomi;Shibata, Rei;Ouchi, Noriyuki
• 通讯作者: Ouchi, Noriyuki

生体組織を活性化する方法及びその装置

激活活体组织的方法和装置

• 发表时间: 2011

Therapeutic lymphangiogenesis with implantation of adipose-derived regenerative cells.

• DOI: 10.1161/jaha.112.000877
• 发表时间: 2012-08
• 期刊: Journal of the American Heart Association
• 影响因子: 5.4
• 作者: Shimizu Y;Shibata R;Shintani S;Ishii M;Murohara T
• 通讯作者: Murohara T

Therapeutic impact of follistatin-like 1 on myocardial ischemic injury in preclinical models.

• DOI: 10.1161/circulationaha.112.115089
• 发表时间: 2012-10-02
• 期刊: Circulation
• 影响因子: 37.8
• 作者: Ogura Y;Ouchi N;Ohashi K;Shibata R;Kataoka Y;Kambara T;Kito T;Maruyama S;Yuasa D;Matsuo K;Enomoto T;Uemura Y;Miyabe M;Ishii M;Yamamoto T;Shimizu Y;Walsh K;Murohara T
• 通讯作者: Murohara T