Molecular mechanism of anti-inflammatory properties of parasympathetic nervous system and its application in pharmacotherapy of abdominal aortic aneurysm

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In the present study, we investigated the effect of donepezil, an acetylcholinesterase inhibitor, on the endotoxin-induced inflammation in macrophage cells. As results, donepezil reduced the expression and secretion of pro-inflammatory cytokines by attenuating the LPS-induced nuclear translocation of NF-kB. Neither acetylcholine nor other acetylcholinesterase inhibitors reproduced the anti-inflammatory action of donepezil, indicating that donepezil directly affects cells via a mechanism which is independent of its pharmacological property of acetylcholinesterase inhibition.