Non-invasive therapeutic angiogenesis for critical limb ischemia

我们研究了低能量冲击波治疗的安全性和有效性，以开发一种治疗难治性外周动脉疾病的非侵入性方法。治疗前后分别行经皮氧分压（TcPO 2）、皮肤灌注压（SPP）及99 mTc-TF血管造影，观察微循环血流变化。99 mTc-TF的TcPO 2值和灌注指数显著增加。治疗后SPP有升高趋势，但无显著性差异。尽管所有患者均服用一种或多种抗血小板药物，但未发生出血和疼痛等不良事件。

We investigated the safety and efficacy of a low-energy shock waves therapy in order to develop a non-invasive method for intractable peripheral arterial disease. To assess microcirculation blood flow, transcutaneous oxygen tension (TcPO2), skin perfusion pressure (SPP) and 99mtechnetium-tetrofosmin (99mTc-TF) scintigraphy were performed before and after therapy. The value of TcPO2 and perfusion index using 99mTc-TF increased significantly. SPP tended to increase after therapy, but there was no significant difference. There was no adverse event such as bleeding and pain, despite all the patientsin this study were taking one or more antiplatelet agents.