The role of defensins in acute exacerbation of interstitial pneumonia

防御素在间质性肺炎急性加重中的作用

• 批准号: 23790913
• 负责人: SAKAMOTO Noriho
• 金额: $ 2.41万
• 依托单位: Nagasaki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23790913/
• 关键词: 急性増悪; 特発性肺線維症; デフェンシン; バイオマーカー; ARDS

In the present study, we examined the plasma levels of alpha-defensins and beta-defeinsins in patients with acute exacerbation of interstitial pneumonias to determine the role of defensins in the pathogenesis of acute exacerbation of interstitial pneumonias and the possibility of the biomarker of acute exacerbation of interstitial pneumonias.In the present study, we showed that the levels of plasma alpha-defensins were elevated in patients with acute exacerbation of interstitial pneumonias compared with stable interstitial pneumonias, but not the levels of beta-defeinsins.Levels of plasma alpha-defensins did not significantly correlate with clinical parameters and prognosis.We will contineu basic experiments, although these experiments such as making a model of intratrachial injection of defensins were not performed in the study duration.

在本研究中，我们检测了间质性肺炎急性加重患者血浆中α-防御素和β-防御素的水平，以确定防御素在间质性肺炎急性加重发病机制中的作用以及作为间质性肺炎急性加重生物标志物的可能性。我们发现与稳定的间质性肺炎相比，间质性肺炎急性加重患者的血浆α-防御素水平升高，血浆α-防御素水平与临床指标及预后无明显相关性，但未进行防御素模型的建立等基础实验，我们将继续进行基础实验。

项目成果

CT画像解析による肺リンパ脈管筋腫症の気腫性病変の検討

CT图像分析检查肺淋巴管平滑肌瘤病的肺气肿病变

• 发表时间: 2013
• 作者: Okada;Y.;K. Oh-oka;Y. Nakamura;K. Ishimaru;S. Matsuoka;K. Okumura;H. Ogawa;M. Hisamoto;T. Okuda;and A. Nakao;黒沼 幸治;藤澤朋幸，飯野和美，橋本大，須田隆文，千田金吾，前川真人;坂本憲穂
• 通讯作者: 坂本憲穂

Interstitial pneumonia associated with linear immunoglobulin A/immunoglobulin G bullous dermatosis.

与线性免疫球蛋白 A/免疫球蛋白 G 大疱性皮肤病相关的间质性肺炎。

• DOI: 10.1159/000351427
• 发表时间: 2013
• 期刊: Respiration
• 影响因子: 3.7
• 作者: Kakugawa T;Tomimura S;Hayashi T;Sakamoto N;Ishimatsu Y;Mukae H;Kohno S.
• 通讯作者: Kohno S.

Elevated levels of myeloid-related protein-14 in serum and bronchoalveolar lavage fluid in patients with idiopathic pulmonary fibrosis

特发性肺纤维化患者血清和支气管肺泡灌洗液中骨髓相关蛋白14水平升高

• 发表时间: 2011
• 作者: Sakamoto N;Ishimatsu;Kakugawa T;Nakashima S;Hara A;Hara S;Fujita H;Mukae H and Kohno S
• 通讯作者: Mukae H and Kohno S

Serum heat shock protein 47 levels are elevated in acute exacerbation of idiopathic pulmonary fibrosis

• DOI: 10.1007/s12192-013-0411-5
• 发表时间: 2013-09-01
• 期刊: CELL STRESS & CHAPERONES
• 影响因子: 3.8
• 作者: Kakugawa, Tomoyuki;Yokota, Shin-ichi;Kohno, Shigeru
• 通讯作者: Kohno, Shigeru

Serum HSP47 levels in patients with drug-induced lung disease

药源性肺病患者血清HSP47水平

• 发表时间: 2014
• 作者: Takita E;Yokota S;Tahara Y;Hirao A;Aoki N;Nakamura Y;Nakao A;Shibata S;藤澤朋幸，澤木ゆかり，名倉理教，八木達也，山田尚広，菊池直香，橋本大，前川真人;角川智之
• 通讯作者: 角川智之