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The role of defensins in acute exacerbation of interstitial pneumonia

The role of defensins in acute exacerbation of interstitial pneumonia
防御素在间质性肺炎急性加重中的作用
批准号:
23790913
负责人:
SAKAMOTO Noriho
金额:
$2.41万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012

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中文摘要
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英文摘要
In the present study, we examined the plasma levels of alpha-defensins and beta-defeinsins in patients with acute exacerbation of interstitial pneumonias to determine the role of defensins in the pathogenesis of acute exacerbation of interstitial pneumonias and the possibility of the biomarker of acute exacerbation of interstitial pneumonias.In the present study, we showed that the levels of plasma alpha-defensins were elevated in patients with acute exacerbation of interstitial pneumonias compared with stable interstitial pneumonias, but not the levels of beta-defeinsins.Levels of plasma alpha-defensins did not significantly correlate with clinical parameters and prognosis.We will contineu basic experiments, although these experiments such as making a model of intratrachial injection of defensins were not performed in the study duration.
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会议论文
CT画像解析による肺リンパ脈管筋腫症の気腫性病変の検討
CT图像分析检查肺淋巴管平滑肌瘤病的肺气肿病变
DOI: --
发表时间: 2013
期刊:
影响因子: --
作者: [Okada, Y., K. Oh-oka, Y. Nakamura, K. Ishimaru, S. Matsuoka, K. Okumura, H. Ogawa, M. Hisamoto, T. Okuda, and A. Nakao, 黒沼 幸治, 藤澤朋幸,飯野和美,橋本大,須田隆文,千田金吾,前川真人, 坂本憲穂]
通讯作者: 坂本憲穂
Interstitial pneumonia associated with linear immunoglobulin A/immunoglobulin G bullous dermatosis.
与线性免疫球蛋白 A/免疫球蛋白 G 大疱性皮肤病相关的间质性肺炎。
DOI: 10.1159/000351427
发表时间: 2013
期刊: Respiration
影响因子: 3.7
作者: [Kakugawa T, Tomimura S, Hayashi T, Sakamoto N, Ishimatsu Y, Mukae H, Kohno S.]
通讯作者: Kohno S.
Elevated levels of myeloid-related protein-14 in serum and bronchoalveolar lavage fluid in patients with idiopathic pulmonary fibrosis
特发性肺纤维化患者血清和支气管肺泡灌洗液中骨髓相关蛋白14水平升高
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [Sakamoto N, Ishimatsu, Kakugawa T, Nakashima S, Hara A, Hara S, Fujita H, Mukae H and Kohno S]
通讯作者: Mukae H and Kohno S
DOI: 10.1007/s12192-013-0411-5
发表时间: 2013-09-01
期刊: CELL STRESS & CHAPERONES
影响因子: 3.8
作者: [Kakugawa, Tomoyuki, Yokota, Shin-ichi, Kohno, Shigeru]
通讯作者: Kohno, Shigeru
13
    Regulation of lung fibrosis targeting NETs
    • 批准号:
      17K09618
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.0万
    • 财政年份:
      2017
    • 负责人:
      SAKAMOTO Noriho
    • 依托单位:
    海外基金