Th2 type innate immune response and prolonged air inflammation induced by fungus

Th2型先天免疫反应与真菌引起的长期空气炎症

• 批准号: 23790921
• 负责人: TOMOMATSU Katsuyoshi
• 金额: $ 2.75万
• 依托单位: Tokai University (2012)Keio University (2011)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23790921/
• 关键词: 自然免疫; 真菌; Th2型気道炎症

In recent years, the mechanism of type 2 innate immune responsethat may be involved in the pathophysiology of allergic diseases such as asthma has been elucidated rapidly. In the present study, I examined the mechanisms of innate type-2immune reaction to fungal antigen in the airways. The response was dependent on protease activity of fungi, but not dependent on IL-33 or natural helper cells. In the study using Ja18KO mouse or IL-17RB antibody, airway inflammation was suppressed, suggesting thatIL-25 derived from NKT cells was involved

近年来，2型天然免疫应答的机制已被迅速阐明，它可能参与过敏性疾病如哮喘的病理生理。在本研究中，我研究了气道中对真菌抗原的天然2型免疫反应的机制。该反应依赖于真菌的蛋白酶活性，但不依赖于IL-33或天然辅助细胞。在使用Ja 18 KO小鼠或IL-17 RB抗体的研究中，气道炎症被抑制，表明来源于NKT细胞的IL-25参与其中

项目成果

アスペルギルス抗原に対する気道のIL-33非依存性2型自然免疫応答

呼吸道中对曲霉菌抗原的不依赖于 IL-33 的 2 型先天免疫反应

• 发表时间: 2013
• 作者: 友松克允;小熊剛;加川志津子;加畑宏樹;宮田純;友松裕美;鈴木雄介;福永興壱;浅野浩一郎
• 通讯作者: 浅野浩一郎

Th2 type airway inflammation induced by Aspergillus extracts

曲霉提取物诱导的Th2型气道炎症

• 发表时间: 2011
• 作者: K Tomomatsu;T Oguma;S Kagawa;KFukunaga;Y Suzuki;M Kodama;H Ogura;N Kamiishi;J Miyata;K Tanaka;HKabata;K Sayama;K Asano
• 通讯作者: K Asano

Th2-type innate immune response in the airways induced by Aspergillus extracts

曲霉提取物诱导气道中的 Th2 型先天免疫反应

• 发表时间: 2011
• 作者: K Tomomatsu;T Oguma;S Kagawa;KFukunaga;Y Suzuki;M Kodama;H Ogura;N Kamiishi;J Miyata;K Tanaka;HKabata;K Sayama;K Asano;友松克允
• 通讯作者: 友松克允