Th2 type innate immune response and prolonged air inflammation induced by fungus

近年来，2型先天免疫应答可能参与哮喘等变应性疾病病理生理的机制被迅速阐明。在本研究中，我研究了呼吸道真菌抗原的先天2型免疫反应的机制。这种反应依赖于真菌的蛋白酶活性，而不依赖于IL-33或天然辅助细胞。在使用Ja18KO小鼠或IL-17RB抗体的研究中，气道炎症被抑制，提示来自NKT细胞的atil -25参与其中

In recent years, the mechanism of type 2 innate immune responsethat may be involved in the pathophysiology of allergic diseases such as asthma has been elucidated rapidly. In the present study, I examined the mechanisms of innate type-2immune reaction to fungal antigen in the airways. The response was dependent on protease activity of fungi, but not dependent on IL-33 or natural helper cells. In the study using Ja18KO mouse or IL-17RB antibody, airway inflammation was suppressed, suggesting thatIL-25 derived from NKT cells was involved