Pathological role of dendritic cell in IgA nephropathy

脾细胞伊加的产生在低锌条件下较高，而在高锌条件下较低。锌对B细胞产生伊加的调节作用在DC存在下被强调。膳食锌可能促进免疫过程中产生致肾炎伊加。我们的数据表明，饮食锌调节改变了DC的活性，并导致IgAN的程度。因此，结果建立了补充锌和小鼠IgAN活性之间的联系。

IgA production by spleen cells is higher in low Zn condition, and lower in high Zn condition. The influence of Zn regulation on IgA production by B cell is emphasized in the presence of DCs. Dietary Zn condition may enhance the immunological process for producing nephritogenic IgA. Our data demonstrate that dietary Zn regulation alters the activity of DCs and results in the extent of IgAN. Thus, the results establish a link between supplemental Zn and activity of IgAN in mice.