Elucidation of the lung and kidney cross-talk in acute kidney injury(AKI) and evaluation of urinary midkine as a diagnostic marker of AKI.

阐明急性肾损伤 (AKI) 中的肺和肾交互作用以及评估尿中期因子作为 AKI 诊断标志物。

• 批准号: 23790967
• 负责人: HAYASHI Hiroki
• 金额: $ 2.66万
• 依托单位: Fujita Health University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23790967/
• 关键词: 腎臓学; AKI; 肺腎連関; ミッドカイン; 急性腎障害; AKI：acute kidney injury; 臓器連関; 肺腎クロストーク; ALI/ARDS; AKIバイオマーカー; ミドッカイン

We have retrospectively studied a cohort of 2579 patients admitted to the intensive care unit. The total AKI prevalence was 30% according to the AKIN criteria and after adjustment for covariates, AKIN stages remained independently associated with in-hospital mortality. An observational, retrospective analysis has been performed for 52 ALI/ARDS patients controlled by the noninvasive positive pressure ventilation (NPPV). Various cytokine levels were elevated in bronchoalveolar lavage from ALI/ARDS patients who developed AKI. These biomarkers were sensitive predictor of the NPPV failures. These findings strongly suggested the organ cross-talk between kidney and lung in ALI/ARDS. Finally we have confirmed the potential of urinary midkine as a novel biomarker for the early detection of AKI.

我们回顾性研究了2579例入住重症监护室的患者。根据AKIN标准，总阿基患病率为30%，在调整协变量后，AKIN分期与住院死亡率独立相关。对52例采用无创正压通气（NPPV）控制的ALI/ARDS患者进行了观察性回顾性分析。在发生阿基的ALI/ARDS患者的支气管肺泡灌洗液中，各种细胞因子水平升高。这些生物标志物是NPPV失败的敏感预测因子。这些结果强烈地提示了ALI/ARDS时肾和肺之间的器官串扰。最后，我们证实了尿中期因子作为早期检测阿基的新型生物标志物的潜力。

项目成果

当院集中治療室(ICU)における急性腎障害(AKI)について

关于我院重症监护病房（ICU）急性肾损伤（AKI）

• 发表时间: 2011
• 作者: Lasiene J.;Yamanaka K;新城響
• 通讯作者: 新城響

Clinical nephrology 全身性疾患と腎障害 肺・腎連関

临床肾脏病学 全身性疾病和肾脏疾病 肺肾关系

• 发表时间: 2012
• 期刊: Annual Review腎臓
• 作者: Kashiwagi T;Hayama N;Fujita E;Hara K;Mii A;Masuda Y;Iino Y;Shimizu A;Katayama Y;Fukuda Y;湯澤 由紀夫
• 通讯作者: 湯澤 由紀夫

Distant Effects of AKI on Lung Injuries by Soluble Mediators in Broncho-Alveolar Lavage Fluid in Patients with Acute Lung Injury / Acute Respiratory Distress Syndrome

急性肺损伤/急性呼吸窘迫综合征患者支气管肺泡灌洗液中可溶性介质对 AKI 肺损伤的远距离影响

• 发表时间: 2012
• 作者: 仁木(高橋)加寿子;仁木剛史;有賀(井口)早苗;有賀寛芳;Hiroki Hayashi
• 通讯作者: Hiroki Hayashi

A Comparison of the Acute Kidney Injury Network and Kidney Disease : Improving Global Outcomes Criteria for Acute Kidney Injury in Critically Ill Patients

急性肾损伤网络与肾脏疾病的比较：改善危重患者急性肾损伤的全球结局标准

• 发表时间: 2011
• 作者: Tanaka R;Sasaki-Ikesawa K;Shimura H;Nishioka K;Hattori N;Tanaka S;Kaji R.;Shinjo H
• 通讯作者: Shinjo H

【AKIの管理Q&A-救急・集中治療のための質問237-】 総論 多臓器不全を合併したAKIの診断は、どのようにしますか?(Q&A/特集)

【AKI管理问答-急诊及重症监护第237题】总则：AKI并发多器官功能衰竭如何诊断（问答/专题）

• 发表时间: 2012
• 期刊: 救急・集中治療
• 作者: Fujita E;Shimizu A;Kaneko T;Masuda Y;Ishihara C;Mii A;Higo S;Kajimoto Y;Kanzaki G;Nagasaka S;Iino Y;Katayama Y;Fukuda Y;林 宏樹
• 通讯作者: 林 宏樹